despite instead in places of in spite 四个词（词组）的区别

despite尽管=inspite of
Despite her illness,she still went to school.
instead 为副词,多用于句子的开头,结尾.意思为代替
He can't eat meat ,so he has to have fish instead.
in place of代替 多用于句中
Will you go in place of me?