in charge of 与take charge of的区别是什么?

take charge of 是开始管理,接管的意思,是主动 .
eg:The boss asked him to take charge of the office for a few days while she was away.(老板让他在她离开时掌管办公室几天)
in charge of 负责
be responsible for=be in charge of =take charge of 对...负责任,负责...