怎么回答Is there no one home

怎么回答Is there no one home
英语中回答反义疑问句要根据事实回答.那请问在回答一般问题是也要注重这个原则吗?
比如这句怎么回答
Is there no one home?
A.No there is B.Yes,there is C.No,there isn't D.Yes,there isn't
假如我要回答的意思是“家里确实没人”。